Description
Position summary :
The Laboratory of Neuroimmunology at the University Hospital of Lausanne () is primarily devoted to research in Multiple Sclerosis (MS). We are studying the interaction between the immune response, and environmental factors, in particular, Epstein-Barr virus (EBV). To extend our understanding of autoimmunity in central nervous system (CNS) disorders including MS , we have developed a unique autologous model using human induced pluripotent stem cells derived CNS cells. We are now seeking a highly motivated Postdoctoral researcher to join our team to specifically investigate the role of autoreactive CD8+ T cells in the MS pathogenesis, with an emphasis on their interactions with central nervous system (CNS) cells and EBV infection. This position offers an exciting opportunity to work with cutting-edge techniques and contribute to discoveries in the field of neuroimmunology.
The Lausanne University Hospital (CHUV) is one of five Swiss university hospitals. Through its collaboration with the Faculty of Biology and Medicine of the University of Lausanne and the EPFL, CHUV plays a leading role in the areas of medical care, medical research and training.
MissionThe opportunity :
- Design and conduct of experiments
- To characterize the pool of autoreactive CD8+ T cells in MS patients versus healthy controls including TCR repertoire analyses
- To assess the cross-reactivity between EBV antigens and hiPSC-derived CNS cells.
- Collaborate with laboratory and clinical team members and external partners
- Manuscript writing and contribution to grant applications
- Present findings at national and international conferences.
Your profile :
- Ph.D. in Immunology, Neuroscience, Cell Biology, or any equivalent
- Strong background in T cell immunology AND/OR neurobiology including
- Experience with hiPSC culture and differentiation,
- AND/OR proficiency in immunological assays such a flow cytometry, ELISPOT, etc.
- AND/OR Experience with -omics large-scale dataset analyses such, in particular scRNAseq.
- Problem-solving and organization skills
- Excellent written and oral communication skills
- Commitment to teamwork and collaboration.
Resources:
Our laboratory offers state-of-the-art facilities, including:
- Culture laboratory for hiPSC reprogramming and differentiation into CNS cells
- Advanced flow cytometry and cell sorting systems
- Genomic and proteomic analysis tools
- Bioinformatics and computational biology support
To become an employee of the world-famous University Hospital Center from the Canton of Vaud is an assurance of:
- First-rate social benefits such as a Paternity Leave of 20 days and a Maternity Leave of 4 months (there is also the possibility to obtain a complementary breastfeeding leave of 1 month)
- Regular salary progression adapted to your responsibilities
- A 13th salary and 25 days of vacations per year
- A right to at least three days of training per year, by accessing a wide offer of courses not only from the CHUV Training Center but also from external providers
- Possibility to access one of the 500 furnished apartments offered in the surrounding neighborhoods in case of relocation in Switzerland
- Discounts proposed on social and cultural events, goodies and other services, thanks to the “H-Oxygène” association
- Signing up to our Mobility Plan and benefit from different advantages (discounts on public transportation, promotion of “Mobility” car fleet and discounts on electric bikes)
- Being able to enjoy our high-quality corporate restaurants, located in every hospital building, with employees’ discount
Contact person in case of questions about this role : Dre Amandine Mathias, +41 (0) 21 314 55 21
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